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Professor Utonium hopes that he will create three perfect little girls, using a mixture of sugar, spice and everything nice to improve Townsville, a fictional city plagued by crime. He is shoved by his laboratory assistant and a destructive chimpanzee named Jojo, but he accidentally breaks a flask of a mysterious substance called Chemical X that spills into the mixture and explodes in Jojo's face. The Professor realizes that the experiment is successful, having produced three little girls, whom he names Blossom (the smart and mature one), Bubbles (the cute and bubbly one) and Buttercup (the rough and tough one). They also have superpowers as a result of the additional Chemical X, though they all immediately grow to love each other as a family. At the insistence of the Mayor, the girls agree to use their powers to defend Townsville and become the city's beloved crime-fighting team of superheroes: the Powerpuff Girls.