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On a remote former submarine refueling facility called Aquatica, a team of scientists are searching for a cure for Alzheimer's disease. Dr. Susan McAlester genetically engineers three Mako sharks, intending to increase their brain capacity so that they can harvest the tissue as a cure for Alzheimer's. Unfortunately, the increased brain capacity also makes the sharks smarter, faster, and more dangerous. Aquatica's financial backers are skeptical and nervous about the tests, and send a corporate executive to visit the facility.